姚 萌¹，魏玉颖¹，邓晓东²，黄德莲³，马雨臻¹，许春叶¹，陈丽如¹，李 伟¹，杜彦锋¹，王星月¹，唐崇邵¹，张薇薇^1*

（1.成都医学院公共卫生学院，成都610500；2.成都医学院第一附属中医医院，成都市新都区中医医院，成都610500；3.夹江仙草谷生物科技有限公司，夹江县华头镇辕门村股份经济合作社，乐山614100）

摘要：石斛是我国传统名贵药材之一，具有增强免疫力、抗氧化、抗肿瘤、降血糖等功效，在健康医疗方面备受关注。石斛的主要有效成分毛兰素（Erianin）是一种低分子量联苄类天然化合物，多项研究证实Erianin对肺癌、乳腺癌、结直肠癌、肝癌等多种肿瘤具有明显的抑制作用；其机制涉及增强机体免疫力、抑制肿瘤血管生成、调控细胞周期、促进肿瘤细胞凋亡、对抗癌药物的增效作用等，与PI3K/AKT、MAPK、Wnt/β-catenin、cGAS-STING等多种信号途径有关，同时通过抗炎作用辅助肿瘤治疗。该文就国内外近5年相关文献，分别对Erianin在抗肿瘤效应、机制、信号途径方面进行了归纳与总结，以期为Erianin在防治肿瘤和临床运用中提供参考。

关键词：毛兰素；抗肿瘤；分子机制；信号通路

中图分类号：R285 文献标识码：A 文章编号：1674-506X（2025）05-0103-0006

Research Progress on the Anti-tumor Effect and Mechanism of Activity Component Erianin in Dendrobium

YAO Meng¹，WEI Yuying¹，DENG Xiaodong²，HUANG Delian³，MA Yuzhen¹，XU Chunye¹，CHEN Liru¹，LI Wei¹，DU Yanfeng¹，WANG Xingyue¹，TANG Chongshao¹，ZHANG Weiwei^1*

（1.School of Public Health，Chengdu Medical College，Chengdu 610500，China；

2.The First Affiliated Hospital of Traditional Chinese Medicine of Chengdu Medical College，Chengdu Xindu District Hospital of Traditional Chinese Medicine，Chengdu 610500，China；

3.Jiajiang Xiancaogu Biotechnology Co.，Ltd.，The Joint-stock Economic Cooperative of Yuanmen Village，Huatou Town，Jiajiang County，Leshan 614100，China）

Abstract: Dendrobium is one of the traditional valuable medicinal herbs in China， which has the efficacy of enhancing immunity，antioxidation，anti-tumor and lowering blood glucose，and has attracted much attention in healthcare. erianin， the main active component of Dendrobium， is a low molecular weight bibenzyl natural compound. Several studies have confirmed that erianin has obvious inhibitory effects on various tumors，such as lung， breast， colorectal and liver cancers， etc. Its mechanism involves enhancing body immunity， inhibiting tumor angiogenesis，regulating cell cycle，promoting tumor apoptosis，synergizing effects on anticancer drugs and so on. It is also related to various signaling pathways such as PI3K/AKT，MAPK，Wnt/β-catenin，cGAS-STING pathway，etc.，and at the same time，it assists in tumor therapy through anti-inflammatory effects. This paper is based on related domestic and foreign literatures in recent 5 years， summarizes the anti-tumor effects，mechanisms and signaling pathways of erianin，providing references for the prevention and treatment of tumors and the clinical application of erianin.

Keywords: erianin；anti-tumour；molecular mechanism；signaling pathway

doi: 10.3969/j.issn.1674-506X.2025.05-013