于纯淼¹，于苗苗¹，陈小倩¹，廖 贤¹，郑时嘉²，付佳琪¹，于栋华^*

（1.黑龙江中医药大学，黑龙江哈尔滨 150040；

2.天问山生物科技股份有限公司，黑龙江哈尔滨 150300）

摘要：为了探究参蛹精杞含片（ShenYongJingQi lozenge，SYJQ）的缓解体力疲劳作用和机制，将雄性昆明小鼠分为正常对照组、阳性对照组、参蛹精杞含片低剂量组［2.9 g/（kg·bw）］、中剂量组［5.8 g/（kg·bw）］和高剂量组［11.6 g/（kg·bw）］，通过力竭游泳实验以及测定疲劳相关生化指标，评价参蛹精杞含片对小鼠体力疲劳的影响。研究发现，与正常对照组相比，参蛹精杞含片能延长力竭游泳时间，增加肌糖原（Muscle Glycogen，MG）、肝糖原（Liver Glycogen，LG）储备量和乳酸脱氢酶（Lactate dehydrogenase，LDH）活力，降低乳酸（Lactic acid，LA）、血尿素氮（Blood Urea Nitrogen，BUN）含量及肌酸激酶（Creatine Kinase，CK）活力。结果表明：参蛹精杞含片表现出缓解体力疲劳作用，可为开发具有缓解体力疲劳功能的保健产品提供依据。

关键词：参蛹精杞含片；缓解体力疲劳；力竭游泳实验；机理；药食同源

中图分类号：TS218.2     文献标识码：A      文章编号：1674-506X（2023）03-0047-0005

Study on the Anti-fatigue Effect of ShenYongJingQi Lozenge

YU Chunmiao¹, YU Miaomiao¹, CHEN Xiaoqian¹, LIAO Xian¹, ZHENG Shijia²

, FU Jiaqi¹, YU Donghua^1*

(1.Heilongjiang University of Chinese Medicine，Harbin Heilongjiang 150040,China;

2.Tianwenshan Biotechnology Co., Ltd., Harbin Heilongjiang 150300,China)

Abstract：To study the anti- fatigue effect of ShenYongJingQi lozenge （SYJQ）. The experiment randomly divided the mice normal control group, positive control group，SYJQ lozenge low-dose group (2.9 g/kg· bw), middle-dose group (5.8 g/kg· bw) and high-dose group (11.6 g/kg·bw). Exhaustive swimming test and fatigue related biochemical indexes were selected to evaluate the effect of lozenge on physical fatigue in mice. The study found that compared with the control group, SYJQ lozenge can prolong exhausted swimming time, increase muscle glycogen (MG), liver glycogen (LG) reserves and the activity of lactate dehydrogenase,reduce the content of lactic acid (LA) and blood urea nitrogen (BUN),it could also decrease the activity of creatine kinase. The results showed that SYJQ lozenge has an effect of anti-fatigue and can provide basis for the development of health food with anti-fatigue function.

Keywords: ShenYongJingQi lozenge; anti-fatigue; exhausted swimming test; mechanism; homology of medicine and food

doi: 10.3969/j.issn.1674-506X.2023.03-008

收稿日期：2022-09-29

基金项目：黑龙江省应用技术研究与开发计划项目（GA20C017）；黑龙江中医药大学科研基金项目（2019BJP04）

作者简介：于纯淼（1978－），男，博士，副教授。研究方向：中药保健食品研制与开发。

*通信作者：于栋华（1979-），女，博士，副研究员。研究方向：中药药性理论及药效物质基础研究。

引用格式:于纯淼,于苗苗,陈小倩,等.参蛹精杞含片缓解体力疲劳作用实验研究[J].食品与发酵科技,2023,59(3):47-51.