李方珅，张振国，萨木哈尔·胡安，阿卜杜喀哈尔·如则麦麦提，王卓瑜，丁红*
（新疆医科大学公共卫生学院，乌鲁木齐830017）
摘要：为研究麸皮膳食纤维及益生菌酸奶对四氯化碳（CCl4）诱导的小鼠急性肝损伤的保护作用，将小鼠进行适应性喂养后随机分组，分别饲喂麦麸、益生菌酸奶、麦麸＋益生菌酸奶，经诱导急性肝损伤后测定小鼠血液中谷丙转氨酶（ALT）活性、谷草转氨酶（AST）活性、超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量、肝脏指数，并观察肝脏组织形态。结果表明：麦麸协同益生菌酸奶可有效降低肝脏水肿程度以及有效缓解CCl4所致的急性肝损伤；益生菌酸奶可显著提高机体抗氧化能力、清除自由基以及显著降低机体的脂质过氧化程度；麦麸组、酸奶组及麦麸＋酸奶组均可改善肝细胞变性、肿胀、坏死、炎性细胞浸润的病理现象。麸皮膳食纤维协同益生菌酸奶对CCl4诱导的肝损伤小鼠的保护作用优于麦麸或益生菌酸奶单独作用，可有效缓解肝脏损伤程度，提高机体抗氧化能力。
关键词：麸皮膳食纤维；益生菌酸奶；急性化学性肝损伤
中图分类号：R575.2 文献标识码：A 文章编号：1674-506X（2025）04-0081-0006
Experimental Study on the Protective Effect of Bran Dietary Fiber and Probiotic Yogurt on CCl4-induced Acute Liver Injury in Mice
LI Fangshen，ZHANG Zhenguo，SAMUHAER · Huan，ABUDUKAHAER · Ruzemaimaiti，WANG Zhuoyu，DING Hong*
(School of Public Health，Xinjiang Medical University，Urumqi 830017，China)
Abstract: In order to study the protective effect of bran dietary fiber and probiotic yogurt on carbon tetrachloride（CCl4）- induced acute liver injury in mice， mice were randomly divided into groups after adaptive feeding，different groups were fed with wheat bran， probiotic yogurt， wheat bran ＋ yogurt. The activities of alanine aminotransferase （ALT）， aspartate aminotransferase （AST）， superoxide dismutase （SOD）， malondialdehyde （MDA） content and liver index were determined in mice blood after induction of acute liver injury， and the morphology of liver tissues was observed. The results showed that wheat bran combined with probiotic yogurt could effectively reduce the degree of liver edema and effectively alleviate the acute liver injury caused by CCl4. Probiotic yogurt could significantly improve the body’s antioxidant capacity，scavenge free radicals and significantly reduce the degree of lipid peroxidation in the body. The wheat bran group，yogurt group and wheat bran＋yogurt group could all improve the pathological phenomena of hepatocyte degeneration，swelling，necrosis and inflammatory cell infiltration. The protective effect of wheat bran dietary fiber combined with probiotic yogurt on CCl4-induced liver injury in mice was better than that of wheat bran or probiotic yogurt alone，which could effectively alleviate the degree of liver injury and improve the antioxidant capacity of the body.
Keyword: bran dietary fiber；probiotic yogurt；acute chemical liver injury
doi: 10.3969/j.issn.1674-506X.2025.04-012
