郭 琰，胡 靖，杨婧娟，马雅鸽，赵声兰^*

（云南中医药大学中药学院，云南省高校外用给药系统与制剂技术研究重点实验室，云南省傣医药与彝医药重点实验室，云南昆明 650500）

摘要：三七茎叶资源丰富，研究发现三七茎叶皂苷是其防治疾病的主要生物活性物质，功效日益受到瞩目。近年来，随着生物技术的不断发展，生物技术在中药资源的加工、药理研究以及分离纯化方面取得了突破性进展。本文总结了近年来三七茎叶皂苷生物转化技术的研究成果，为综合利用三七茎叶及其特色食品、保健食品和新药开发等提供新的途径，为中药学与生物工程、食品工程等现代生命科学的前沿学科相结合奠定基础。

关键词：三七茎叶；皂苷；生物转化

中图分类号：TS218    文献标识码：A    文章编号：1674-506X（2022）02-0111-0006

Research Progress in Biotransformation of Stem and Leaf Aaponins of Panax notoginseng

GUO Yan, HU Jing, YANG Jingjuan, MA Yage, ZHAO Shenglan^*

（Yunnan Key Laboratory of Dai and Yi Medicines, The Key Laboratory of External Drug Delivery System and Preparation Technology in University of Yunnan Province, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming Yunnan 650500, China）

Abstract：The stem and leaf resources of Panax notoginseng are abundant. Studies have found that the stem and leaf saponins of P. notoginseng are the main bioactive substances for disease prevention and control, and their efficacy has attracted increasing attention. In recent years, with the continuous development of biotechnology, breakthroughs have been made in the processing technology, pharmacological research, separation and purification of traditional Chinese medicine resources. In this paper, the research achievements on the biotransformation technology of stem and leaf saponins of P. notoginseng in recent years were summarized, which provided a new way for the comprehensive development and utilization of stem and leaf of P. notoginseng and its characteristic food, health food and new drug development, and provided a basis for the combination of traditional Chinese medicine with the frontier disciplines of modern life science, such as bioengineering and food engineering.

Keywords：notoginseng leaf; saponins; biotransformation

doi：10.3969/j.issn.1674-506X.2022.02-017

收稿日期：2021-09-23

基金项目：云南省重大科技专项计划（202002AA1000055，202102AE09003）；云南省科技厅-云南中医药大学联合专项重点项目（2019FF002-006）

作者简介：郭琰（1997-），女，硕士研究生。研究方向：中药质量控制与评价。

*通信作者：赵声兰（1962-），女，教授。研究方向：药食资源研究与开发利用。

引用格式：郭琰,胡靖,杨婧娟,等.生物转化三七茎叶皂苷研究进展[J].食品与发酵科技,2022,58(2):111-116.